67 institutions reported holding $116.6M of SPRUCE BIOSCIENCES INC (SPRB) in SEC 13F filings for 2026-06-30. Largest institutional holders: AIGH Capital Management LLC ($13.5M), ORBIMED ADVISORS LLC ($10.8M), BlackRock, Inc. ($10.1M), MILLENNIUM MANAGEMENT LLC ($8.7M), VANGUARD GROUP INC ($8.5M). Source: SEC Form 13F.
Source: SEC Form 13F filings · as of 2026-06-30